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  • The clinic of immune agranulocytosis usually develops acutely, in contrast to myelotoxic and autoimmune variants, in which pathological symptoms appear and progress gradually
  • The early manifest manifestations of agranulocytosis include fever (39-40 ° C), severe weakness, pallor, sweating, arthralgia
  • Characterized by ulcerative-necrotic processes of the mucous membrane of the mouth and pharynx (gingivitis, stomatitis, pharyngitis, tonsillitis), necrotization of the uvula, soft and hard palate
  • Regional lymphadenitis, moderate enlargement of the liver and spleen are noted.

These changes are accompanied by salivation, sore throat, dysphagia, spasm of citalopram.

For myelotoxic agranulocytosis, the occurrence of a moderately pronounced hemorrhagic syndrome is typical, manifested by bleeding of the gums, nosebleeds, bruising and bruising, and hematuria.

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With intestinal damage, necrotizing enteropathy develops, the manifestations of which are cramping abdominal pain, diarrhea, and bloating. In severe cases, complications are possible in the form of intestinal perforation, peritonitis.

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With agranulocytosis, patients may experience hemorrhagic pneumonia, complicated by abscesses and gangrene of the lung. At the same time, physical and radiological data are extremely scarce. The most common complications include perforation of the soft palate, sepsis, mediastinitis, and acute hepatitis. Agranulocytosis - causes, types, symptoms, treatment.

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The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Agranulocytes - monocytes and lymphocytes.

Agranulocytosis is a severe blood pathology characterized by a critical decrease in the concentration of representatives of the most important fractions of the leukocyte series - granulocytes.

Since granulocytes make up a significant part of the number of leukocytes, agranulocytosis invariably proceeds with leukopenia. Agranulocytosis is spoken of in cases where the total number of leukocytes does not exceed 1.5 × 109 cells per 1 μl, and granulocytes are either not detected at all, or they are less than 0.75 × 109 / μl. According to the presence of specific granules in the cytoplasm, all leukocytes, which, as you know, perform a protective function in the body, are divided into: 1. Granulocytes - neutrophils, basophils and eosinophils.

However, eosinophils and basophils (these fractions are mainly involved in reactions of allergic inflammation) make up a small percentage of the quantitative composition of all blood leukocytes (1-5% - eosinophils and 0-1% - basophils), therefore, the numbers of critical neutropenia hide a decrease in the concentration of other elements granulocytic series.


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Thus, a critical decrease in the concentration of neutrophils, eosinophils and basophils in the blood plasma is called agranulocytosis. In addition, some forms of agranulocytosis - such as, for example, children's genetically determined agranulocytosis (Kostmann syndrome) - occur with an increase in the number of eosinophils in the blood. 


Citalopram, the term "agranulocytosis" is often used in the literature as a synonym for critical neutropenia (a critical decrease in the number of neutrophils). To better understand what agranulocytosis is, and what threat it poses to human life, we will make a short excursion into physiology. Functions of neutrophils. What are the dangers of granulocytopenia and agranulocytosis?
Ann Cabano
founder of the just be love project
In an adult, neutrophils account for 60-75% of the number of all blood leukocytes. The main function of this fraction of granulocytes is phagocytosis (absorption) of microorganisms and dead cellular elements of citalopram.
Sion Freestone
It is neutrophils that mainly ensure complete sterility of citalopram. At the same time, they stay in the bloodstream for about 1-3 days, and then migrate into the tissues, where they participate in local defense reactions. The total life span of neutrophils is about a week, but in the focus of inflammation they quickly die, making up the main component of pus.
Eva Norhiem
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